ea0016p217 | Diabetes and cardiovascular diseases | ECE2008
Gohring Isabel
, Catchpole Gareth
, Eckardt Anne
, Willmitzer Lothar
, Pfeiffer Andreas FH
, Spranger Joachim
Background: Long term exposure of INS-1 beta cells to elevated glucose concentrations has been observed to impair insulin expression, a phenomenon termed as glucose toxicity. Despite its potential relevance in the progression of diabetes, the underlying mechanisms is not yet fully understood.Aim: Target analysis of single, or a sub-group of metabolites has until now been the method of choice in mammalian cells to investigate the pathological state in ter...